
While the Bible doesn’t say anything about the “the spirit of Jezebel,” the Bible does say a lot about the historical evil person Jezebel. Satan certainly wants people to act like this evil woman.
It shouldn’t be our normal practice to block people from our lives in an extreme way. If, for example, you like a man but it doesn’t work out, you may need to distance yourself for a bit so you can move on; but it’s not necessary to go to severe lengths so there is no evidence of his presence at all in your life.